Experimental Design & Data Integration Consulting

Design Smarter Studies, Build Cohesive, Multidimensional Insights

ImmSilico provides expert guidance in crafting rigorous, high-impact experimental designs tailored to the complexities of tissue immunity. We help ensure your studies are not only biologically relevant, but also statistically powered, technically feasible, and analytically integratable.

Whether you’re planning a single-cell, spatial, or multi-omic study—or combining all three—we offer strategic support to help you develop cohesive, scalable study designs that drive actionable discovery.

Specific Services We Offer

• Experimental Design Consulting

• Define objectives and hypotheses aligned with biological and technical constraints

• Choose appropriate technologies and sample sizes (e.g., for rare populations like tissue-resident Tregs)

• Ensure replicates and control arms are sufficient for comparison

• Guide metadata capture and cross-platform protocol design

• Power Analysis & Statistical Frameworks

• Estimate sample size needs for detecting cell state shifts, niche remodelling, or clonotype expansion

• Account for batch effects, heterogeneity, and longitudinal sampling

• Develop robust statistical plans for treatment vs control comparisons

• Data Integration Strategy

• Design for integration across scRNA-seq, spatial, proteomics, and imaging platforms

• Develop frameworks for aligning cross-modality datasets

• Plan for integration early—normalisation, anchors, and transfer learning

• Public Data & Reference Atlas Mapping

• Identify relevant public datasets for annotation, benchmarking, and alignment

• Support label transfer, signature enrichment, and cross-study harmonisation

• Align with atlases (e.g., Healthy Colon, IBD, CPI-colitis)

• Training & Capacity Building

• Deliver workshops and one-on-one support for study design and integration pipelines

• Tailor onboarding for academic, startup, or resource-limited teams

Use case and Track Record

• Designed a multi-platform IBD study integrating human and murine scRNA-seq, spatial data, and CyTOF to uncover crypt-niche remodelling and inflammatory signatures

• Developed a comparative design for checkpoint inhibitor-induced colitis vs. ulcerative colitis using spatial and TCR tracking

• Led the statistical design and sampling plan for a tumour study on antigen-specific CD4/CD8 T cells using tetramers and single-cell sequencing

Start With a Smarter Foundation

We help you design reproducible, powerful, and integrative studies—right from the start.

Contact Us: contact@immsilico.com