Experimental Technology & Feasibility Consulting

Empowering Discovery Through The Right Experimental Strategies

At ImmSilico, we help researchers and organisations navigate the rapidly evolving landscape of experimental technologies to design successful studies in tissue immunity. Whether you’re exploring single-cell transcriptomics, spatial platforms, TCR/BCR sequencing, or novel antigen-specific tools, we provide expert, unbiased guidance on choosing the most suitable technologies—tailored to your scientific goals, sample constraints, and budget.

We support your team in making informed, evidence-based decisions—helping to minimise technical and logistical risks while maximising scientific outcomes.

Specific Services We offer

• Technology Evaluation & Selection

• Compare and evaluate platforms for scRNA-seq, TCR-seq, and spatial transcriptomics (e.g., 10x Genomics, CosMx, Visium, Nanostring)

• Assess compatibility with study goals (e.g., tracking antigen-specific T cells, identifying niche-resident populations)

• Recommend platform combinations (e.g., scRNA-seq + tetramers, CITE-seq + VDJ, CyTOF + imaging)

• Feasibility Assessments

• Evaluate sample input, tissue type, and processing constraints

• Assess model system suitability (e.g., endogenous vs model antigen)

• Identify technical bottlenecks (e.g., cell recovery, library prep, detection limits)

• Custom Panel & Protocol Design

• Advise on antibody panels, tetramers, spatial probes, and multimodal reagents

• Guide metadata design and technical replicate planning

• Optimise niche-cell workflows (e.g., stromal enrichment in mesenchymal studies)

• Pilot Study Design & Risk Assessment

• Plan proof-of-concept studies before large-scale rollout

• Support grant applications with pilot rationale and platform justification

• Vendor & Partnership Strategy

• Recommend trusted vendors and CROs

• Assist with quote review, timeline estimates, and assay feasibility checks

Use Case and Track Record

• Designed a single-cell + TCR-seq workflow to track antigen-specific CD4/CD8 T cells in a mouse tumour model using GP33 tetramers

• Supported the use of CosMx spatial transcriptomics to identify CPI-bound T cells in CPI-colitis tissue

• Developed a dissociation and QC pipeline to enrich crypt niche mesenchymal cells from inflamed human colon tissue

Questions About a Project?

Let’s discuss your experimental goals and help you choose the most powerful, cost-effective technologies for your needs.

Contact Us: contact@immsilico.com